An international research program on the associations between environmental stressors, climate, and health

  • Human-induced climate change

    Global warming already responsible for one in three heat-related deaths between 1990-2018, and being Central and South America and South-East Asia most affected regions.

    (Vicedo-Cabrera et al. Nature Climate Change 2021)

  • almetric

    Scientific contribution

    Outstanding altmetric scorings for the MCC Collaborative Research Network includes,

    • 2 papers ranked top 100
    • 5 papers ranked top 200
  • The MCC Network

    Currently including data on environmental stressors, climate, and health over 768 cities/communities from 44 countries, representing a wide range of climates worldwide.

  • ISEE Conference

    The MCC Collaborative Research Network members will contribute substantially to the 33nd annual conference of the International Society for Environmental Epidemiology (ISEE 2021) Virtual Conference by presenting a keynote lecture and 2 E-Poster communications.

  • Paris Agreement

    Trends in changes in excess mortality projected for warming in 2 °C, 3 °C and 4 °C, relative to 1.5 °C, by geographic region and climate zone across 451 cities/communities in 23 countries.

    (Vicedo-Cabrera et al. Climate Change 2018)

  • COVID-19 and climate

    Keynote Session Estimating the Role of Climate in Modulating SARS-CoV-2 Transmission Dynamics: An Ecological Analysis across 500 Cities


    Watch it here

  • Mortality attributable

    Global assessment of the health effects of temperature on mortality, exploring the increased health risks and impact associated with both high and low temperature across various climates and populations.

    (Gasparrini et al. Lancet 2015).

  • Climate change projections

    Climate change projections of temperature-related health impacts under various scenarios of climate change and different assumptions of adaptation and population changes, coupled with the assessment of the potential effects of alternative mitigation strategies.

    (Gasparrini et al. Lancet Planet Health 2017)

  • Vulnerability

    Global assessment of the health effects of temperature on mortality, exploring the increased health risks and impact associated with both high and low temperatures across various climates and populations.

    (Sera et al. Int J Epidemiol 2019)

  • Air pollution

    Evidence on an independent effect of particulate matter in increasing the risk of mortality, consistently across 652 cities in 24 countries.

    (Liu et al. N Engl J Med 2019)

  • Suicide and temperature

    Linear and nonlinear short-term associations between ambient temperature and suicide mortality to varying extents across 341 locations in 12 countries.

    (Kim et al. Environ Health Perspect 2019)

  • NEJM Notable Articles of 2019

    The MCC paper Ambient particulate air pollution and daily mortality in 652 cities has been selected by the Editors of the New England Journal of Medicine among the Notable Articles of 2019.


The Multi-Country Multi-City (MCC) Collaborative Research Network is an international collaboration of research teams working on a program aiming to produce epidemiological evidence on associations between environmental stressors, climate, and health. Interest on these topics has grown in the last few years among both researchers and the general public, due to recent events of extreme weather or pollution and to alarming climate change scenarios, all linked with increased health risks.

The research program benefits from the use of the largest dataset ever assembled for this purpose, including information on environmental exposures, health outcomes, and climate projections from hundreds of locations within several countries around the world. This allows standardized analyses on local data to address specific research questions on global environment-health associations, following a formalized yet flexible method of collaboration.

The MCC Collaborative Research Network has developed during the years, through correspondence between the participants and additional meetings held at scientific conferences. The MCC Collaborative Research Network is currently coordinated by the LSHTM research team, with the support of a Scientific Committee that supervises and directs the research work.

You can also follow the latest news and publications of the MCC Collaborative Research Network on Twitter at @mccstudy 

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