An international research program on the associations between environmental stressors, climate, and health

  • The MCC Network

    Currently including data on environmental stressors, climate, and health over 1,150 locations from 53 countries, representing a wide range of climates worldwide.

  • Mortality attributable

    Global assessment of the health effects of temperature on mortality, exploring the increased health risks and impact associated with both high and low temperature across various climates and populations.

    (Gasparrini et al. Lancet 2015).

  • Air pollution

    Evidence on an independent effect of particulate matter in increasing the risk of mortality, consistently across 652 cities in 24 countries.

    (Liu et al. N Engl J Med 2019)

  • Climate change projections

    Climate change projections of temperature-related health impacts under various scenarios of climate change and different assumptions of adaptation and population changes, coupled with the assessment of the potential effects of alternative mitigation strategies.

    (Gasparrini et al. Lancet Planet Health 2017)


The Multi-Country Multi-City (MCC) Collaborative Research Network is an international collaboration of research teams working on a program aiming to produce epidemiological evidence on associations between environmental stressors, climate, and health. Interest on these topics has grown in the last few years among both researchers and the general public, due to recent events of extreme weather or pollution and to alarming climate change scenarios, all linked with increased health risks.

The research program benefits from the use of the largest dataset ever assembled for this purpose, including information on environmental exposures, health outcomes, and climate projections from hundreds of locations within several countries around the world. This allows standardized analyses on local data to address specific research questions on global environment-health associations, following a formalized yet flexible method of collaboration.

The MCC Collaborative Research Network has developed during the years, through correspondence between the participants and additional meetings held at scientific conferences. The MCC Collaborative Research Network is currently coordinated by the LSHTM research team, with the support of a Scientific Committee that supervises and directs the research work.

You can also follow the latest news and publications of the MCC Collaborative Research Network on Twitter at @mccstudy 

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